Label: VARDENAFIL tablet, orally disintegrating

Sildenafil citrate, sold as Viagra, and under various other trade names, is a drug used to treat erectile dysfunction and pulmonary arterial hypertension (PAH).

5.11 Effects on Bleeding

Advise patients of the contraindication of vardenafil with regular and/or intermittent use of organic nitrates. Inform patients of the potential cardiac risk of sexual activity for patients with preexisting cardiovascular risk factors. Inform patients that in some patients concomitant use of PDE5 inhibitors, including vardenafil, with alpha-blockers can lower blood pressure significantly leading to symptomatic hypotension (for example, fainting). Patients prescribed vardenafil who are taking alpha-blockers should be started on the lowest recommended starting dose. Patients should be advised to contact the prescribing physician if other anti-hypertensive drugs or new medications that may interact with vardenafil are prescribed by another healthcare provider.

Does vardenafil interact with other medicines (drug interactions)?

Discuss with patients the appropriate use of vardenafil and its anticipated benefits. It should be explained that sexual stimulation is required for an erection to occur after taking vardenafil. It should be taken approximately 60 minutes before sexual activity. Patients should be counseled regarding the dosing of vardenafil especially regarding the maximum daily dose. Patients should be advised to contact their healthcare provider for dose modification if they are not satisfied with the quality of their sexual performance with vardenafil or in the case of an unwanted effect. It acts by inhibiting cGMP-specific phosphodiesterase type 5, an enzyme that delays degradation of cGMP, which regulates blood flow in the penis.

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Mahipat Patel (Director) Centurion Laboratories Private LimitedBiotech Park Gidc, P-2, Manjusar, Savli, Vadodara Vadodara - 391770, Gujarat, India Vardenafil is an oral drug that is used to treat impotence, the inability to attain or maintain a penile erection. It has a mechanism of action that is similar to sildenafil (Viagra), and tadalafil (Cialis). Penile erection is caused by the engorgement of the penis with blood. This engorgement occurs when the blood vessels delivering blood to the penis increase in size and increase the delivery of blood to the penis. At the same time, the blood vessels carrying blood away from the penis decrease in size and decrease the removal of blood from the penis.

Liver Dose Adjustments

The mean Cmax and area under the plasma concentration time curves (AUC) increased in an almost dose-proportional manner. Vardenafil has a mean absolute bioavailability of 15%. The rate and extent of absorption did not alter when vardenafil 20 mg was administered immediately after a typical meal (approximately 30% of calories as fat) compared with in the fasting state. A high-fat meal (57% of calories as fat), however, reduced the rate of absorption with an increase in time to maximum plasma concentration (Tmax) of 1 hour and reduced the Cmax by 18% [6]. According to the authors’ personal experience in the use of all three available PDE5 inhibitors, it is wise to suggest to patients to initially use them with an empty stomach (at least two hours after completion of a meal) to maximise the therapeutic effect and optimise onset time.

How should I store vardenafil?

Responders are then routinely allowed to ingest these drugs irrespective of food or alcohol intake, with the possibility that the overall therapeutic effect may be reduced. Providing you the best range of vardenafil 60 mg tablet, vilitra vardenafil 20 mg tablets, vilitra vardenafil 60 mg tablets, vilitra 10 mg tablets, vilitra 20 mg tablets and vilitra vardenafil 80 mg tablets with effective & timely delivery. Vardenafil is a PDE5 inhibitor used for treating impotence. Vardenafil''s indications and contra-indications are the same as with other PDE5 inhibitors; it is closely related in function to sildenafil citrate (Viagra) and tadalafil (Cialis).Vardenafil''s relatively short effective time is comparable to but somewhat longer than sildenafil''s. Packaging Details: VILITRA PROFESSIONAL 4/10 tablets Vilitra 20 Tablet is used to treat erectile dysfunction in men. Sexual stimulation that leads to the engorgement and erection causes the production and release of nitric oxide in the penis. Nitric oxide then activates the enzyme, guanylate cyclase to produce cyclic guanosine monophosphate (cGMP). The cGMP is primarily responsible for increasing and decreasing the size of the blood vessels carrying blood to and from the penis, respectively.

• Vardenafil 10 mg tablets treat erectile dysfunction in men.
• The medication works by increasing blood flow to the penis.
• Take vardenafil 10 mg about 30 minutes before activity.
• It can be taken with or without food, but high-fat meals may delay effects.
• Maximum recommended dose is one tablet per 24 hours.
• Vardenafil may cause side effects like headache or flushing.
• Do not use vardenafil if you take nitrates for chest pain.
• Consult a doctor before using vardenafil if you have heart problems.
• Store vardenafil tablets at room temperature, away from moisture.
• Alcohol can increase side effects of vardenafil.

Vardenafil prevents an enzyme called phosphodiesterase-5 (PDE-5) from destroying cGMP so that cGMP persists longer. The longer cGMP persists, the more prolonged the engorgement of the penis. Vardenafil was approved by the FDA in August 2003.

What happens if I overdose?

Advise patients to stop treatment and seek medical attention in the event of sudden loss of vision in one or both eyes. Inform patients of the increased risk of NAION in individuals who have already experienced NAION in one eye and discuss the increased risk of NAION among the general population in patients with a "crowded" optic disc, although evidence is insufficient to support screening of prospective users of PDE5 inhibitor, including vardenafil, for this uncommon condition. Advise patients to stop treatment and seek prompt medical attention in the event of sudden decrease or loss of hearing. It is not possible to determine whether these events are related directly to the use of PDE5 inhibitors or to other factors. The use of vardenafil offers no protection against sexually transmitted diseases.

What are the serious side effects of vardenafil?

Counseling of patients about protective measure necessary to guard against sexually transmitted diseases, including the Human Immunodeficiency Virus (HIV), should be considered. Advise patients that the disintegrating tablet (Staxyn) is not interchangeable with the film-coated tablet (Levitra). General Notes: May be taken with or without food. (Tablet) Place on tongue to disintegrate; take without liquid and immediately upon removal from blister. Studies in men with ED have shown that single doses of vardenafil 10–40 mg were rapidly absorbed following oral administration, with maximum plasma concentrations (Cmax) reached in some men within 15 minutes (median 0.6–0.9 hours) (Table 2) [4,5]. The most common side effects of vardenafil are Vardenafil also may cause chest pain, low blood pressure, blurred vision and changes in color vision, abnormal ejaculation and priapism (painful erection lasting more than 6 hours).

Brand Name	Manufacturer	Formulation Type	Price Range	Notes
Levitra	Bayer	Tablet	Moderate	Widely used
Staxyn	Bayer	Orally disintegrating tablet	Similar price	Alternative formulation
Generic Vendors	Multiple	Tablet	Lower	Cost-effective option

Patients should seek immediate medical help if they experience an erection lasting more than 4 hours. Rare cases of sudden loss of hearing have been reported with phosphodiesterase inhibitors such as vardenafil, sometimes associated with ringing in the ears and dizziness. If changes in hearing occur, patients should discontinue their vardenafil and seek immediate medical attention. For most individuals, the recommended dose of vardenafil regular tablets is 10 mg per day taken 60 minutes before intercourse.

• The onset of vardenafil 10 mg is typically 30-60 minutes.
• It can last up to 4-5 hours in some users.
• Vardenafil is contraindicated with certain heart medications.
• Use caution if you have a history of hypotension.
• The tablet may cause mild gastrointestinal upset.
• Do not consume large amounts of alcohol when taking vardenafil.
• Inform your doctor if you experience sudden hearing loss.
• Use only as directed by your healthcare provider.
• Discontinue if you experience persistent erection issues.
• The medication does not increase sexual desire.

If there is no response or side effects, the dose may be increased to 20 mg or, if there are side effects, it may be reduced to 5 mg. Individuals 65 years of age or older should begin therapy with 5 mg.

• Vardenafil 10 mg is a selective phosphodiesterase type 5 inhibitor.
• It can improve the ability to achieve an erection.
• Maintain open communication with your healthcare provider.
• Use with caution in elderly patients.
• Report any unusual side effects promptly.
• The medication should not be used recreationally.
• Not recommended for use with certain antihypertensives.
• Effectiveness depends on correct timing and dosage.
• Avoid taking if you have severe liver disease.
• Always read the patient information leaflet.

Individuals who are taking medications that increase the blood levels of vardenafil should start treatment with 2.5 to 5 mg of vardenafil. Orally disintegrating tablets (ODT) are not interchangeable with regular vardenafil tablets because they are better absorbed and produce higher blood levels than regular tablets.

Parameter	Result	Notes
Absorption Time	30-60 minutes	Time to peak plasma concentration (Tmax)
Bioavailability	~15%	Percentage of dose reaching systemic circulation
Half-life	4-5 hours	Duration of effect
Metabolism	Liver (CYP3A4 enzyme)	Mainly via hepatic pathways
Excretion	Feces (~60%), Urine (~20%)	Primary routes

The recommended dosing when using ODT is one tablet 60 minutes before intercourse.

How does the online consultation work?

All these tablets are made by using qualitative ingredients and in compliance with the established norms and standards of the industry. We offer these tablets in air tight and hygienic packaging, in order to retain its effectiveness. Widely used for the treatment of impotency. We are among the organizations engaged in manufacturing and supplying Vilitra 40 mg Tablets. These vardenafil dapoxetine tablets are formulated in tandem with the norms of the industry by using high-grade ingredients obtained from the authorized vendors of the market. Only one tablet should be used per day. It should be placed on the tongue until it disintegrates and should not be swallowed with water.

Overdose/Missed Dose

It increases blood flow to the penis to help men get an erection. Vardenafil's indications and contra-indications are the same as with other PDE5 inhibitors; it is closely related in function to sildenafil citrate (Viagra) and tadalafil (Cialis).Vardenafil's relatively short effective time is comparable cenforce d 160 to but somewhat longer than sildenafil's. Vilitra 20 Tablet is used to treat erectile dysfunction in men. Vardenafil Tablets F/C is a PDE5 inhibitor used for treating impotence.Vardenafil's indications and contra-indications are the same as with other PDE5 inhibitors; it is closely related in function to sildenafil citrate (Viagra) and tadalafil (Cialis).Vardenafil's relatively short effective time is comparable to but somewhat longer than sildenafil's. We are among the organizations engaged in manufacturing and supplying Vilitra Vardenafil 40 mg Tablets.

What is the dosage for vardenafil?

The Vilitra-40 tablets offered by us are closely related in function to sildenafil citrate (Viagra) & tadalafil (Cialis) and are used for symptomatic treatment of Erectile Dysfunction. Vilitra 10 Tablet is used to treat erectile dysfunction in men. We are among the reputed manufacturer and supplier of Vardenafil Tablets F/C. Offered range of vardenafil tablets is also used for treating impotency. These tablets are similar to sildenafil citrate (Viagra) and tadalafil (Cialis), but cures the disease in shorter period of time. Ultrafine Wildfire Smoke Particles May Pose Serious Health Risks High Fitness Doesn't Raise A-fib Risk in Young Men Weight Loss Program Helps Women Battling Breast Cancer Cheaper, Alternative Health Plans Are Having a Moment Antibiotics Won't Help Ease Asthma-Linked Wheezing in Kids The breakdown and elimination of vardenafil from the body is inhibited by erythromycin, clarithromycin (Biaxin), ketoconazole (Nizoral), itraconazole (Sporanox), indinavir (Crixivan), ritonavir (Norvir), atazanavir (Reyataz), grapefruit juice.